The Exeter-based company has agreed a two-year contract flying agreement with the Belgium airport. Pilots, cabin crew and engineering support will be provided by Flybe.
The aircraft will carry the livery of Brussels Airport but will operate under the Flybe Airline Operating Certificate.
Chairman and chief executive Jim French said: "The partnership with Brussels Airlines is an exciting development for Flybe and we are delighted to be working with such a respected European operator.
"It is also further confirmation of our reputation as a quality provider of professional turn-key solutions in the regional aviation market.
"Given the success of the identical partnership we had with Olympic Airline in 2009-10, we are confident that the partnership with Brussels Airlines will progress extremely well and also pave the way for further partnerships as we continue to seek to optimise the use of our existing fleet."
The airport reported an 18 per cent increase in revenue in the three months to 31 December 2011 with total sales of £165.5m.
Source: Insider
